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R&D Scientist - T-Cell Immunotherapies

Company: Actalent
Location: Arcadia
Posted on: September 17, 2022

Job Description:

Description:Our R & D team is seeking a motivated, collaborative, and highly skilled Scientist with passion for developing T cell-based immunotherapies to treat hematologic malignancies and solid tumors. Candidate is expected to work across the various aspects of preclinical development and validation of novel T cell / antibody therapeutics. He / She will work closely with our internal colleagues and external collaborators to efficiently progress early-stage cell therapy products through to IND filing. This position will report directly to the Director of Research & Development, immunotherapy.The successful candidate has extensive experience in a combination of skills including, genetic manipulation of T cells and tumor cells using viral/nonviral methods, VCN determination using qPCR/ddPCR, T/NK cell isolation, optimization of culture conditions, immunophenotyping, development and optimization of a variety of assays (molecular, cell based, biochemical, immunological) for preclinical validation of cell therapy products.

  • Lead planning, design, and execution of experiments related of development and characterization of cellular immunotherapy products in coordination with R & D director.
  • Analyze, and report complex data to cross functional teams in a clear and concise manner
  • Mentor and train scientific staff on technical skills required to effectively perform experiments and to facilitate progression of projects
  • Manage multiple research projects simultaneously with the R & D team and collaborate with other departments (Process Science, Analytical Science, Quality, Manufacture) as necessary.
  • Contribute to various preclinical projects within R& D and those required by clients through in-depth scientific knowledge and demonstrated experience in analytical methods used in cellular immunotherapy field
  • Performs a wide range of non-routine exploratory experiments as required
  • Maintain precise laboratory notebooks, electronic records following high standards of data quality and integrity.
  • Prepare scientific/technical reports, summaries, protocols, etc, and present them to internal and external stakeholders.
  • Constantly improvise research strategies and adopt technologies to stay upfront in the field of immunotherapySkills & Qualifications:
    • Antibody experience
    • Molecular biology experience
    • Dna manipulation/joining pieces of dna together (dna cloning)
    • Cell engineering
    • Experience in phage display library construction, antibody engineering or affinity maturation of antibodies ---. 3-4 years
    • Cell based assayy & mammalian cell culturingMasters + 5 yrs of experience (maybe 2 years is ok if its very specific to antibodies)
      • Experience: mammalian cell culture, antibody & phage display technology, assays, dna, pcrPh. D in the field of Immunology, Cell biology, Virology or Cancer biology or related life science discipline with 3+ years (Scientist) or 5+ years (Senior Scientist)

        About Actalent:

        Actalent connects passion with purpose. Our scalable talent solutions and services capabilities drive value and results and provide the expertise to help our customers achieve more. Every day, our experts around the globe are making an impact. We're supporting critical initiatives in engineering and sciences that advance how companies serve the world. Actalent promotes consultant care and engagement through experiences that enable continuous development. Our people are the difference. Actalent is an operating company of Allegis Group, the global leader in talent solutions.
        The company is an equal opportunity employer and will consider all applications without regards to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

Keywords: Actalent, Arcadia , R&D Scientist - T-Cell Immunotherapies, Other , Arcadia, California

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